Radiomimetic beverages, drugs, and mutagens.
نویسندگان
چکیده
منابع مشابه
Mutagens in coffee and other beverages.
A cup of coffee contains mutagens which produce about 5 X 10(4)-10(5) revertants of Salmonella typhimurium TA 100 without S9 mix. One of the mutagens was identified to be methylglyoxal. Methylglyoxal was present in various beverages such as black tea, whisky, and brandy. Methylglyoxal itself induced tumors in rats when administered by subcutaneous injection. However, the mutagenic properties of...
متن کاملThe Role of Foods and Beverages in the Effectiveness of Drugs
Foods and nutrients in them are one of the most important and variable factors affecting the bioavailability and function of oral drugs in the body. Foods affect the effectiveness of drugs in different ways. Just as medications often reduce the absorption of nutrients, foods often reduce the effectiveness of medications; food in the stomach delays the absorption of penicillin and amoxicillin an...
متن کاملRadiomimetic Model
Direct selection for 12 mutations (blm) conferring hypersensitivities to lethal effects of bleomycins in Saccharomyces cerevisiae resulted in mutants exhibiting cross-hypersensitivity to ionizing radiation and hydrogen peroxide. Remaining mutations did not confer cross-hypersensitivity to radiation. All blm mutations were recessive, except codominant blm3-1, and were assigned to seven complemen...
متن کاملDesmutagenicity Mutagens of Melanoidins againstVariousKinds of Mutagens and Actiyated In
ND-MEL and LM-MEL exhibited a desmutagenic activity of 25-75% against mutagenic aromatic or heterocyclic compounds such as aflatoxin Bi, B[ct]P, 2-aminofluorene, 4-aminobiphenyl, and 2-aminonaphthalene, as well as heterocyclic amines, using S. mphimurium TA98 in the presence of S9 mix. In the case of using S. mphimurium TAIOO in the absence of S9 mix, ND-MEL and LM-MEL showed a desmutagenic act...
متن کاملMutation and Mutagens Definitions
somatic mutation: a mutation in a somatic cell; somatic mutations produce "mosaic" or "chimeric' organisms since they have sectors of cells with different genotypes. In some plants and fungi tissue from the "mutant" sector may be grown into a whole reproducing organism; some of our better apple varieties arose from mutant sectors on a tree. Somatic mutations in animals can lead to cancer when g...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1966
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.55.6.1431